Proteomics, Saliva, and Sjögren's Syndrome

Practical Approach to Treatment of Sjögren's Syndrome – Dry Mouth and Gynecologic Complaints

Sjogren’s syndrome (SS) is characterized by dry eyes and dry mouth, but there is a wide spectrum of additional symptoms due to dryness. The treatment of dry mouth remains largely unsatisfactory and the correlation of dry mouth symptoms with either minor salivary biopsies or salivary gland flow rates remains low. These currently used methods of diagnosis (and therapeutic outcome) measure predomi...

Evaluation of sialometry and minor salivary gland biopsy in classification of Sjögren's Syndrome patients Summary

Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays.

Sjögren’s syndrome (SS) is a chronic, progressive autoimmune disease primarily affecting women. Diagnosis of SS requires an invasive salivary gland tissue biopsy and a long delay from the start of the symptoms to final diagnosis has been frequently observed. In this study,we aim to identify salivary autoantibody biomarkers for primary SS (pSS) using a protein microarray approach. Immune-respons...

Salivary biomarkers and proteomics: future diagnostic and clinical utilities

Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 9...

Cell Death in Murine Sjögren's Syndrome for Fas Ligand-Mediated Activation-Induced Possible Role of Organ-Specific Autoantigen